Skip to main content
SMFM 2026 Pregnancy Meeting Main banner
Icon Legend
This session is not in your schedule.
This session is in your schedule. Click again to remove it.
Presentation Icons
Additional registration fee required
Additional registration fee required
Faculty have requested this content not be shared outside of the session
Faculty have requested this content not be shared outside of the session
CME Credit Offered
CME Credit Offered
Abstract Award
Abstract Award
Recording available 2/16-5/2
Recording available 2/16-5/2
AIUM Credit
AIUM Credit
Foundation Awardee
Foundation Awardee
Poster Icons
Abstract Award
Abstract Award
Foundation Awardee
Foundation Awardee

Poster Session 1

Category: Antepartum Fetal Assessment

Poster Session 1

(336) Association of cerebroplacental ratio and fetal heart morphology and function in the 3rd trimester

Wednesday, February 11, 2026
10:30 AM - 12:00 PM  

    Submitting Author and Presenting Author(s)

  • Rommy H. Novoa, MD, MSc (she/her/hers)

    Research Fellow
    BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona
    Barcelona, Catalonia, Spain

    • Coauthor(s)

  • Lina Youssef, MD, PhD

    Postdoctoral researcher
    BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona
    Barcelona, Catalonia, Spain

  • KA

    Kenny Araujo, MD

    BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain.
    Barcelona, Catalonia, Spain

  • LT

    Lea Testa, MD

    BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain.
    Barcelona, Catalonia, Spain

  • AN

    Ayako Nakaki, MD, PhD

    BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain.
    Barcelona, Catalonia, Spain

  • RC

    Rosa Casas, PhD

    Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
    Barcelona, Catalonia, Spain

  • LB

    Leticia Benitez, MD

    BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona
    Barcelona, Catalonia, Spain

  • IC

    Irene Casas, MD

    BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain.
    Barcelona, Catalonia, Spain

  • MG

    Mariona Genero, MD

    BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona
    Barcelona, Catalonia, Spain

  • RB

    Roger Borras, MSc

    BCNatal – Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain.
    Barcelona, Catalonia, Spain

  • SC

    Sara Castro-Barquero, PhD

    BCNatal Fetal Medicine Research Center
    Barcelona, Catalonia, Spain

  • RE

    Ramon Estruch, MD, PhD

    Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
    Barcelona, Catalonia, Spain

  • BB

    Bart Bijnens, PhD

    BCN Medtech, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain.
    Barcelona, Catalonia, Spain

  • GB

    Gabriel Bernardino, PhD

    BCN Medtech, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain.
    Barcelona, Catalonia, Spain

  • Francesc Figueras, MD, PhD (he/him/his)

    Head of Department
    BCNatal – Barcelona Center for Maternal Fetal and Neonatal Medicine Hospital Sant Joan de Déu and Hospital Clínic, University of Barcelona
    Barcelona, Catalonia, Spain

  • FC

    Francesca Crovetto, MD, PhD

    BCNatal – Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
    Barcelona, Catalonia, Spain

  • EG

    Eduard Gratacós, MD, PhD

    Hospital Clínic Barcelona
    BARCELONA, Catalonia, Spain

  • FC

    Fatima Crispi, MD, PhD

    Hospital Clínic de Barcelona
    BARCELONA, Catalonia, Spain

Objective:

To investigate the association of cerebroplacental ratio (CPR) and fetal cardiac function independently from estimated fetal weight (EFW) in fetuses from high-risk pregnancies.

Study Design:
Secondary analysis of the IMPACT-BCN randomized clinical trial including 913 singleton pregnancies at high-risk for small for gestational age newborns. Fetal ultrasound was performed at 33-34 weeks of gestation including echocardiography and CPR (dividing the pulsatility indices of the middle cerebral artery by the umbilical artery). CPR was considered abnormal below 5th centile. At delivery, N-terminal pro B-type natriuretic peptide (NT-proBNP) was measured in cord blood and considered high if above 90th centile (1668 pg/mL).

Results:
Irrespectively from estimated fetal weight, fetuses with abnormal CPR showed a higher proportion of high NT-proBNP (20.0% vs. 7.7%, p=0.007), smaller cardiac area (25.3 centile (IQR 7.5; 52.9) vs. 36.5 (14.2; 65.8), p=0.024), thinner myocardial septal wall (median 51.5 centile (IQR 24.4; 75.6) vs. 67.7 (39.3; 89.3), p=0.005) and higher proportion of abnormal tricuspid annular plane systolic excursion (28.2% vs. 14.2%, p=0.003) as compared with those with normal CPR. When subdividing the population according to EFW and CPR, those subgroups with abnormal CPR showed the strongest association with abnormal cord blood NT-proBNP (subgroups: fetuses with EFW< p3 and CPR< p5 66.7% vs. EFW≥p3 and CPR< p5 17.0% vs. EFW< p3 and CPR≥ p5 7.1% vs. EFW≥p3 and CPR≥p5 7.7%, p=0.005) (Figure 1).

Conclusion:
CPR is associated with worst fetal cardiac function, independently from estimated fetal weight.