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Poster Session 4

Category: Clinical Obstetrics

Poster Session 4

(1143) Pregnancy Outcomes in Patients with Cystic Fibrosis: A Multicenter Retrospective Study

Thursday, February 12, 2026

3:30 PM - 5:00 PM

Submitting Author(s)

Jasmine A. Rosa, BS (she/her/hers)

Medical Student
University of California, Riverside
Riverside, California, United States

Presenting Author(s)

Kimberley Lepe, MS (she/her/hers)

University of California, Riverside School of Medicine
Riverside, California, United States

Coauthor(s)

SC

Sallie Canumay, DO, MSc

Department of Obstetrics and Gynecology, Riverside University Health System
Moreno Valley, California, United States
BO

Bryan Oshiro, MD

Department of Obstetrics and Gynecology, Riverside University Health System
Moreno Valley, CA, California, United States
Sarah D. Smithson, DO

Riverside University Health System
Moreno Valley, California, United States
DN

Daniel Novak, PhD

University of California Riverside, Riverside
University of California Riverside, Riverside, California, United States
LS

Leonard Soloniuk, MD

Department of Gynecology and Obstetrics, Riverside University Health System
Moreno Valley, California, United States

Objective:
Cystic fibrosis (CF) is a chronic genetic disorder resulting from a mutation of the CFTR gene, historically linked to reduced fertility and adverse pregnancy outcomes. As survival improves, more individuals with CF are pursuing pregnancy, though data on maternal and obstetric outcomes remain limited. We hypothesize that CF increases the risk of adverse maternal outcomes.

Study Design:
We conducted a study using TriNetX, a large database of de-identified electronic patient health records, compiled with the HIPAA Privacy Rule. We used the US Collaborative Network, which includes 169,411,996 patients across 67 healthcare organizations. Pregnant patients with CF were compared to a matched cohort without CF. Outcomes included preterm delivery, preeclampsia, gestational diabetes mellitus, sepsis, eclampsia, chorioamnionitis, postpartum hemorrhage, and maternal mortality. Outcomes were analyzed within 45 weeks of pregnancy diagnosis, except for mortality, which was assessed within 1 year. Propensity score matching (PSM) of demographics and comorbidities was performed. Statistical analyses included risk ratio, two-tailed t-test and 95% confidence intervals with a p-value of < 0.05 defining significance.

Results:
Average age of the cohorts were [29.7+/- 16] for the CF cohort and [29.8+/- 16.2] for the control cohort. Compared to controls, patients with CF had significantly higher rates of preterm delivery [Risk Ratio: (RR) =1.7, (1.266, 2.266), p= .0003], gestational diabetes mellitus [RR=1.4, (1.15,1.67) p= .0006], sepsis [RR=3.3, (2.247, 4.891), p< .0001], and mortality [RR=2.9, (1.942, 4.43), p< .0001]. Controls had significantly higher rates of preeclampsia [RR=.78, (.673, .901) p= .0007]. There was no significant difference in rates of eclampsia, chorioamnionitis or postpartum hemorrhage.

Conclusion:
Pregnant patients with CF are at increased risk for preterm delivery, gestational diabetes mellitus, sepsis, and maternal mortality, but were associated with lower rates of preeclampsia. These findings underscore the need for multidisciplinary care and close monitoring of this vulnerable population.