Poster Session 2
Category: Clinical Obstetrics
Poster Session 2
Shira Gat, DMD
Medical Student
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University
Beer-Sheva, HaDarom, Israel
Tamar Wainstock, PhD (she/her/hers)
Department of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, Ben-Gurion University of the Negev
Beer Sheva, HaDarom, Israel
.jpg "Gali Pariente, MD photo")
Gali Pariente, MD
Acting director of Fetal Maternal Unit B Division of Obstetrics and Gynecology
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University
beer sheva, HaDarom, Israel
.jpeg.jpg "Eyal Sheiner, MD, PhD photo")
Eyal Sheiner, MD, PhD
Deichmann Lerner Full Professor of Obstetrics & Gynecology; Chairman of the Division of OBY&GYN
Soroka University Medical Center, Faculty of Health Sciences, Ben‑Gurion University of the Negev
beer sheva, HaDarom, Israel
Gil Gutvirtz, MD, MHA
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University
Metar, HaDarom, Israel
Birth rates among women aged 30 and above have climbed to record highs, influenced by evolving social and economic dynamics, including greater focus on professional advancement, prolonged educational pursuits, and increased access to fertility treatments. The aim of the study is to assess whether nulliparity at advanced maternal age (AMA) is associated with increased long-term morbidity in offspring.
Study Design:
A population-based retrospective cohort study was conducted at a single tertiary medical center between 1991 and 2021. The cohort included all nulliparous women aged ≥30 years who delivered a live singleton. Participants were stratified into three age groups: 30-35, 36-40, and > 40. Offspring were followed until 18 years of age for the occurrence of long-term cardiovascular, respiratory, endocrine, neurologic, gastrointestinal, or infectious morbidities, based on community-based or hospitalizations. Kaplan–Meier survival analyses and Cox proportional hazards models were used to evaluate cumulative incidence and adjusted hazard ratios for each morbidity category.
Results:
The study included 4,951 women: 3,729 (75.3%) aged 30–35, 946 (19.1%) aged 36–40, and 276 (5.6%) aged > 40. Increasing maternal age was associated with higher rates of hypertensive disorders, gestational diabetes, preterm birth, and cesarean delivery (p < 0.001). However, no significant differences were observed in cumulative incidence of long-term morbidity among offspring across the maternal age groups (Figure). In multivariable analysis adjusted for fertility treatment, ethnicity, cesarean delivery, gestational age, gestational diabetes, and hypertensive disorders, AMA was not independently associated with increased long-term morbidity in any diagnostic category (Table).
Conclusion:
Although AMA is associated with adverse pregnancy outcomes, nulliparity at AMA is not associated with long-term morbidity in offspring.