Poster Session 4
Category: Clinical Obstetrics
Poster Session 4
Maxwell Oberlander, MD
Resident Physician
Maimonides Medical Center
Brooklyn, New York, United States
Rodney A. McLaren, Jr, MD
Maternal Fetal Medicine Attending
Maimonides Medical Center
Brooklyn, New York, United States
Tirtza Spiegel Strauss, MD
Fellow
Maimonides Medical Center
Brooklyn, New York, United States
Henri M. Rosenberg, MD (he/him/his)
Maternal Fetal Medicine Attending
Icahn School of Medicine at Mount Sinai
Icahn School of Medicine at Mount Sinai, New York, United States
Rebecca H. Jessel, MD
Maternal Fetal Medicine Attending
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, NYU Grossman School of Medicine
New York, New York, United States
Alexa L. Cohen, MD
University of Miami
Miami, Florida, United States
Georgios Doulaveris, MD
Maternal Fetal Medicine Attending
Montefiore Medical Center/Albert Einstein College of Medicine
Montefiore Medical Center/Albert Einstein College of Medicine, New York, United States
Pe'er Dar, MD
Professor and Director, Division of Fetal Medicine
Montefiore Medical Center
Bronx, New York, United States
Meghana A. Limaye, MD
MFM Fellow
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, NYU Grossman School of Medicine
NYU Langone, New York, United States
Emily Schlussel Markovic, MD
MFM Fellow
Maimonides Medical Center
Brooklyn, New York, United States
Joselle O'Brien, MA, MD
MFM Fellow
Maimonides Medical Center
Brooklyn, New York, United States
Angela T. Bianco, MD
Professor and Division Director, Maternal-Fetal Medicine
Icahn School of Medicine at Mount Sinai
New York, New York, United States
Shoshana Haberman, MD, PhD
Director, Maternal Fetal Medicine
Maimonides Medical Center
Brooklyn, New York, United States
Scott Chudnoff, MD
Chair, Dept of OBGYN
Maimonides Medical Center
Brooklyn, New York, United States
Itamar Futterman, MD
Director, Complex Obstetrical Surgery, Maternal Fetal Medicine Attending
Maimonides Medical Center
Maimonides Health, New York, United States
Recent evidence suggests that obesity affects placental development, leading to adverse pregnancy outcomes. Whether obesity affects the pathophysiology of placenta accreta spectrum (PAS) is unknown. Thus, the objective of this study was to evaluate if maternal pre-pregnancy body mass index (BMI) correlates with increased PAS grade severity.
Study Design:
A multicenter retrospective cohort study of histopathologically confirmed PAS cases 1/1/2013 - 6/30/2022 at five New York academic institutions. Obstetrical and demographic variables were collected. The cohort was divided into two groups, obese (BMI ≥30 kg/m2) and non-obese (BMI < 30 kg/m2). Univariable analysis was performed comparing variables using chi square test for categorical and Student t-test/Wilcoxon rank sum for continuous data. An ordinal regression analysis was then performed adjusting for statistically significant obstetrical and demographic variables between the two groups, comparing median PAS grade. Finally, we divided the cohort by PAS grades and compared the median BMI in each group.
Results:
A total of 401 cases of PAS were collected. Of these, 166 had a documented histopathological grade of PAS. There were 26 obese patients and 140 non-obese. Demographics are presented in Table 1. The proportion of Black and Hispanic individuals was greater in the obese group (30.8% vs. 14.5% and 11.5% vs 5.1%, respectively, p = 0.025). Individuals in the obese group had a significantly greater number of prior cesarean sections [2 (1,3) vs. 1 (1,2), p = 0.045]. There were no other differences between the two groups in social and obstetrical variables. For the primary outcome, there were no differences in median PAS grade between the obese and non-obese groups [1 (1,2) vs 1 (1,2) p=0.67, regression coefficient -0.35, 95%CI (-0.94-0.22]. Additionally, there were no differences in incidence of obesity and median BMI among the different grades of PAS (Table 2).
Conclusion:
There were no differences in both severity of PAS disease and incidence of PAS grade between obese and non-obese patients with histopathologically confirmed PAS.