Poster Session 1
Category: Epidemiology
Poster Session 1
Adi Malkoff Rabin, BSc, MD, MSc (she/her/hers)
senior doctor
Hillel Yaffe Medical center
Binyamina, HaZafon, Israel
Elkana Kohn, PhD
Shamir Medical Center
Rison Letzion, HaMerkaz, Israel
Ariela Hazan, MSc
Research Coordinator
Shamir Medical Center
Rishon Lezion, HaMerkaz, Israel
Yael Dubowski
Technion- Israel Institute of Technology
Haifa, HaZafon, Israel
Matitiahu Berkovitch
Shamir Medical Center
Rishon Lezion, HaMerkaz, Israel
Ori Hochwald
Rambam Health Care Campus
Haifa, HaZafon, Israel
Liron Borenstein-Levin
Rambam Health Care Campus
Haifa, HaZafon, Israel
Tomer Ziv Baran
Tel Aviv University
Tel Aviv, HaMerkaz, Israel
Liisa Jantunen
University of Toronto
Toronto, Ontario, Canada
Miriam L Diamond
University of Toronto
Toronto, Ontario, Canada
Ido Solt, MD
Rambam Health Care Campus
Haifa, HaZafon, Israel
This is a prospective follow-up of a cohort of pregnant women recruited at delivery in two urban regions: one adjacent to heavy industry, and the other non-industrial, traffic-exposed. 2-3 years later, their children (now toddlers) individual exposure to airborne pollutants was assessed using silicone wristbands worn for 7 days. Pollutant analysis, included PAHs (e.g., pyrene), phthalates (DEP, DMP), and flame retardants (OPEs). Respiratory health was evaluated through validated maternal questionnaires (ISAAC and MoBa). Pollutants were analyzed via GC-MSD; exposure-health associations were tested using correlation and regression models
Results:
94 child-mother dyads were analyzed. Children from the industrial area exhibited significantly higher rates of rhinitis (p=0.016), general health issues (p=0.033), and combined wheezing/allergic events (p< 0.001). Measured levels of indoor pollutants such as DEP and DMP were significantly higher in the non-industrial urban area (p=0.0003 and p=0.0002, respectively). DEP levels correlated positively with respiratory symptoms (p=0.029), while pyrene exposure was associated with increased use of steroids and antihistamines (p=0.011)
Conclusion:
This study highlights the feasibility and utility of non-invasive, personalized exposure assessment in pediatric follow-up of maternal cohorts. Despite lower pollutant levels, the industrial region was associated with greater respiratory morbidity, suggesting that in utero and early-life cumulative exposures—rather than single pollutant concentrations—may drive adverse child health outcomes. These findings underscore the importance of environmental monitoring during pregnancy as part of maternal-fetal risk stratification