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Poster Session 2

Category: Clinical Obstetrics

Poster Session 2

(534) Impact of Opioid Use Disorder on Oxytocin Required for Labor Induction in Term Pregnancies

Wednesday, February 11, 2026

3:30 PM - 5:00 PM

Submitting Author(s)

Hansika R. Kunduru

Case Western Reserve University
Case Western Reserve University, Ohio, United States

Presenting Author(s)

Judy Jiang, MD (she/her/hers)

Case Western Reserve University/MetroHealth Medical Center
Cleveland, Ohio, United States

Coauthor(s)

HH

Hannah Hill, MS

MetroHealth Medical Center
The MetroHealth System, Ohio, United States
JP

Jessica Pippen, MD

MetroHealth Medical Center
Cleveland, Ohio, United States

Objective:
Oxytocin is a neuropeptide proven to impact human labor, lactation and social affinity and is of interest in the study of pain and µ-opioid receptor modulation. Individuals impacted by opioid use disorder (OUD) frequently have µ-opioid receptor dysregulation. In this study we sought to investigate the effect of OUD and the use of medications for opioid use disorder (MOUD) on the effectiveness of synthetic oxytocin in term inductions of labor.

Study Design:
Retrospective case-control study of individuals with term pregnancies undergoing induction of labor with oxytocin from 2020-2024 at an urban safety-net hospital. The total amount of oxytocin required to achieve vaginal delivery and total induction of labor time were compared between those with OUD and those without. The groups were matched by age, parity, gestational age, month of delivery, and body mass index. Wilcoxon rank-sum tests were used to compare numeric variables between two groups.

Results:
211 (106 without OUD and 105 with OUD) individual vaginal deliveries were evaluated in the study. There was no significant difference in total oxytocin dose used in induction between patients with OUD and those who did not have OUD. However, patients with OUD spent an estimated 66 minutes longer in induction after amniotomy than those without OUD (269 minutes versus 335 minutes (p=0.015)). Patients on MOUD spent 76 minutes longer in induction after amniotomy than those not on MOUD (269 minutes vs 345 minutes (p = 0.007)). No statistically significant correlation was found between MOUD dose and oxytocin dose.

Conclusion:
Individuals with OUD were not found to have significantly different total required oxytocin dose to delivery than those without OUD. However, patients with OUD, particularly those on MOUD, experienced significantly longer induction time following amniotomy compared to those without OUD. Further studies are needed to further examine the impact of OUD on induction of labor with oxytocin.