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CME Credit Offered
CME Credit Offered
Abstract Award
Abstract Award
Recording available 2/16-5/2
Recording available 2/16-5/2
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AIUM Credit
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Foundation Awardee
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Abstract Award
Abstract Award
Foundation Awardee
Foundation Awardee

Poster Session 4

Category: Epidemiology

Poster Session 4

(1078) Predictors of Takotsubo Syndrome During Pregnancy and The Puerperium in The United States

Thursday, February 12, 2026
3:30 PM - 5:00 PM  
Objective:
Takotsubo syndrome (TS) or broken heart syndrome, is a rare cardiac condition with comparable mortality to myocardial infarction. Although few case reports highlight TS, population-based data on TS in pregnancy are scarce. We examined the epidemiology of TS during pregnancy and the puerperium in the U.S.

Study Design:

We analyzed 4.1 million pregnancy-related hospitalizations in the National Inpatient Sample (NIS) from 2015 to 2021. ICD codes were used to define TS and other clinical conditions. Logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CI), and receiver operating characteristic (ROC) curve analysis was used to evaluate the predictors of TS. The identified parsimonious model was internally validated using 4.8 million records from the 2010-2015 NIS.

Results:

Results: The prevalence of TS increased from 2015 to 2021 (1.96 to 3.85 per 100,000) Figure A. Patients with TS were older (30.6 years vs 29.1 years; p=0.003), used tobacco (12.9% vs 5.5%; p=0.016) and had dyslipidemia (4.8% vs 0.4%; p=0.023). Additionally, TS patients were more likely to have eclampsia (8.9% vs 0.1%; p=0.001), postpartum hemorrhage (16.1% vs 3.9%, p=0.001), anxiety disorders (17.7% vs 5.8%; p=0.001), major cardiovascular events including postpartum cardiomyopathy (25.8% vs 0.1%, p=0.026), in-hospital mortality (4.0% vs 0.0%; p< 0.001) and longer hospital stay (9.6 vs 2.6 days; p=0.026) Table. In adjusted models, predictors of TS were coronary artery disease, eclampsia, sepsis, molar pregnancy, induced abortion, postpartum hemorrhage, fetal birth defect, stillbirth, acute stress reactions and anxiety disorder. Figure B. The internally validated model had an area under the ROC curve (AUC) of 0.82 (CI:0.75-0.88).

Conclusion:
Several clinical and obstetrical factors were predictive of TS in pregnancy and the puerperium. Future studies evaluating the mechanistic pathways driving these relations may provide a more accurate risk assessment and reduce the incidence of TS and related complications during pregnancy and the puerperium.