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Recording available 2/16-5/2
Recording available 2/16-5/2
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Poster Session 2

Category: Medical/Surgical/Diseases/Complications

Poster Session 2

(673) Long-term outcomes of small-for-gestational-age (SGA) offspring born to mothers with and without uterine malformations

Wednesday, February 11, 2026
3:30 PM - 5:00 PM  

    Submitting Author and Presenting Author(s)

  • Sivan Chocron, MD, N/A

    Resident Physician
    Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University
    Beer Sheva, HaDarom, Israel

    • Coauthor(s)

  • PS

    Polina Schwarzman, MD

    Soroka University Medical Center
    Soroka University Medical Center, HaDarom, Israel

  • Tamar Wainstock, PhD (she/her/hers)

    Department of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, Ben-Gurion University of the Negev
    Beer Sheva, HaDarom, Israel

  • Eyal Sheiner, MD, PhD

    Deichmann Lerner Full Professor of Obstetrics & Gynecology; Chairman of the Division of OBY&GYN
    Soroka University Medical Center, Faculty of Health Sciences, Ben‑Gurion University of the Negev
    beer sheva, HaDarom, Israel

Objective:
Small-for-gestational-age (SGA) neonates are known to be at increased risk for long-term morbidities. Given that uterine malformations, a recognized risk factor for fetal growth restriction, may further compromise fetal development through impaired uteroplacental perfusion, we aimed to evaluate whether these neonates experience higher long-term morbidities compared to SGA neonates born to mothers with normal uterine anatomy.

Study Design:
This retrospective population-based cohort study included all SGA neonates born between 1991 and 2021 at a single tertiary medical center. Multiple gestations and chromosomal abnormalities were excluded. SGA neonates were categorized based on maternal uterine anatomy: malformed versus normal. Long-term cardiovascular, respiratory, neurologic, infectious, and gastrointestinal (GI) morbidities were defined based on recorded hospitalization files. Kaplan-Meier survival curves and Cox proportional hazards models (controlling for maternal age, gestational age and mode of delivery) were used to analyze cumulative incidence and adjusted associations, respectively.

Results:

Among 16,210 SGA neonates, 99 (0.61%) were born to mothers with uterine malformations. Uterine malformations were associated with increased risk of infectious morbidity (OR 1.70; 95% CI 1.10–2.50; p = .002) and GI morbidity (OR 1.70; 95% CI 1.10–2.70; p = .003) (Table). However, using a Cox regression model, only GI morbidity remained significantly associated with uterine malformations (adjusted HR 1.70; 95% CI 1.06–2.72; p = .028), whereas the association with infectious morbidity was no longer significant (adjusted HR 1.62; 95% CI 0.96–2.74; p = .070) (Figure).

Conclusion:

Small for gestational age neonates born to mothers with uterine malformations are at an increased risk for long-term gastrointestinal morbidity, suggesting a potential link between abnormal uterine anatomy and altered fetal gastrointestinal development.