(269) Hypertensive Disorders of Pregnancy and Long-term Cardiomyopathy Risk: A Systematic Review and Network Meta-analysis

 A comprehensive literature search was conducted across PubMed, Cochrane Library, Embase, and Web of Science to identify studies published up to July 2025. Studies were included if they compared hypertensive disorders of pregnancy in relation to cardiomyopathy outcomes, including dilated cardiomyopathy. Data were analyzed using a random-effects model, and heterogeneity was assessed using I² statistics in R software.

Results:
Regarding cardiomyopathy (Figure 1), women with a history of gestational hypertension had a significantly increased risk compared to normotensive pregnancies (OR 2.10; 95% CI 1.56–2.81). A similar increase was observed for preeclampsia versus normotensive pregnancies (OR 1.98; 95% CI 1.62–2.42). No significant difference was found between gestational hypertension and preeclampsia (OR 1.06; 95% CI 0.77–1.46). For DCM (Figure 2), both gestational hypertension (OR 2.70; 95% CI 1.71–4.26) and preeclampsia (OR 2.64; 95% CI 1.80–3.89) were associated with increased long-term risk compared to normotensive pregnancies. The comparison between gestational hypertension and preeclampsia remained non-significant (OR 1.02; 95% CI 0.57–1.82).

Conclusion:
HDP significantly increases the long-term risk of cardiomyopathy and DCM compared to normotensive pregnancies. These findings emphasize the importance of accurate diagnosis and proper management during pregnancy, as well as continued cardiovascular monitoring and follow-up after delivery in women with a history of hypertensive disorders during pregnancy.