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Recording available 2/16-5/2
Recording available 2/16-5/2
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Poster Session 1

Category: Epidemiology

Poster Session 1

(211) Maternal Disability and Risk of Neurodevelopmental Disorders in Offspring: A Nationwide Population-Based Cohort Study

Wednesday, February 11, 2026
10:30 AM - 12:00 PM  

    Submitting Author and Presenting Author(s)

  • Hyungyu Park, MD

    Resident Physician, Department of Obstetrics and Gynecology
    Seoul National University Hospital
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

    • Coauthor(s)

  • DS

    Dong Wook Shin, MD, PhD

    Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, South Korea
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • HC

    Hea Lim Choi, MD

    Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, South Korea
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • JK

    Jio Kim

    Department of Obstetrics and Gynecology, Seoul National University, Seoul, Korea
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • JK

    Ji Hoi Kim, MD, PhD

    Seoul National University Hospital
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • SK

    So Hee Kim, N/A

    Seoul National University Hospital
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • CP

    Chan-Wook Park, PhD

    Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • JP

    Joong Shin Park, PhD

    Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • KH

    Kyung Do Han, PhD

    Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

  • Seung Mi Lee, MD, PhD

    Department of Obstetrics and Gynecology, Seoul National University College of Medicine
    Seoul, Seoul-t'ukpyolsi, Republic of Korea

Objective:

Women with disabilities are vulnerable to adverse perinatal outcomes, yet little is known about the long-term neurodevelopmental outcomes in their children. This study aimed to assess the association between maternal disability and neurodevelopmental disorders (NDDs) in offspring, using a comprehensive national birth cohort.



Study Design:

A retrospective cohort study was performed using data from the Korean National Health Insurance Service database linked to the Korea National Disability Registration System, including 3,515,478 births from 2009 to 2021. Maternal disability was categorized into five types: physical, visual, hearing, intellectual, and others. NDDs, including intellectual disability, developmental delay, and autism spectrum disorder, were identified via ICD-10 codes. The primary outcome was NDD incidence after birth. Cox proportional hazards modeling was used to calculate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs), adjusting for maternal age, infant sex, sociodemographic factors, disability status, parity, delivery mode, multifetal gestation, pre-pregnancy comorbidities, miscarriage history, and pregnancy complications.

Results:

Among 18,983 children born to mothers with disabilities, the incidence rate of NDDs was 4.70 per 1,000 person-years versus 1.03 per 1,000 in children of mothers without disabilities. Fully adjusted models showed significantly higher NDD risk (aHR 3.26; 95% CI: 3.03–3.51) in the disability group. Stratified analysis revealed the highest risk in offspring of mothers with intellectual disability (aHR 14.71; 95% CI: 13.30–16.27), followed by hearing (aHR 2.09), other disabilities (aHR 2.14), visual (aHR 1.65), and physical disability (aHR 1.27). All associations were statistically significant, with CIs excluding the null. (figure)



Conclusion:

Maternal disability is an independent risk factor for NDDs in offspring, with the greatest risk for maternal intellectual disability. These findings highlight the need for early developmental screening, targeted interventions, and comprehensive perinatal care for women with disabilities and their children.