Skip to main content
SMFM 2026 Pregnancy Meeting Main banner
Icon Legend
This session is not in your schedule.
This session is in your schedule. Click again to remove it.
Presentation Icons
Additional registration fee required
Additional registration fee required
Faculty have requested this content not be shared outside of the session
Faculty have requested this content not be shared outside of the session
CME Credit Offered
CME Credit Offered
Abstract Award
Abstract Award
Recording available 2/16-5/2
Recording available 2/16-5/2
AIUM Credit
AIUM Credit
Foundation Awardee
Foundation Awardee
Poster Icons
Abstract Award
Abstract Award
Foundation Awardee
Foundation Awardee

Poster Session 1

Category: Diabetes

Poster Session 1

(127) The Relationship Between Neonatal Hypoglycemia and Maternal Glucose Control During Labor of Individuals with T1D

Wednesday, February 11, 2026
10:30 AM - 12:00 PM  
Objective:
Neonates born to individuals with type 1 diabetes (T1D) are at increased risk for neonatal hypoglycemia. It is hypothesized that avoiding intrapartum maternal hyperglycemia and maintaining glucose levels within 70-110 mg/dL (ACOG) or 63-140 mg/dL (ADA) may reduce fetal hyperglycemia and neonatal hypoglycemia. This study determined the association between clinically significant neonatal hypoglycemia and intrapartum glucose control in individuals with T1D.

Study Design:
This prospective cohort study included individuals with T1D followed at a multidisciplinary high-risk pregnancy clinic at a single tertiary center. All used insulin pumps and continuous glucose monitoring. Maternal clinical variables, intrapartum glucose indices, and neonatal glucose levels were recorded. Clinically significant neonatal hypoglycemia was defined as requiring IV glucose. The association with intrapartum glucose control was analyzed.

Results:
76 individuals and their newborns were included; twin pregnancies were excluded. Compared to those whose neonates experienced hypoglycemia, individuals whose neonates did not, had a higher rate of time in range (TIR) and lower time above range (TAR) (63-140 mg/dL), both 1 hour (80% vs. 53%, p=0.002; 16% vs. 42%, p=0.01) and 24 hours (77% vs. 64%, p=0.004; 15% vs. 27%, p=0.01) before delivery. Time below range (TBR, < 63 mg/dL) did not differ significantly. Using the 70-110 mg/dL range, no significant differences in TIR, TAR, or TBR were observed between groups (Table 1). A higher rate of TIR (63-140 mg/dL) remained independently associated with lower odds of significant neonatal hypoglycemia at both time periods after adjusting for confounders including delivery mode, gestational age, large for gestational age (LGA), and first-/third-trimester TIR. The association at 24 hours lost statistical significance after adjusting for second-trimester TIR. A similar trend was seen in multivariable analysis (Figure 1).

Conclusion:
This study supports the association between improved intrapartum glucose control within 63-140 mg/dL range in T1D and reduced risk of significant neonatal hypoglycemia.