Poster Session 1
Category: Epidemiology
Poster Session 1
Inbal Akavian, MD, MPH
Hadassah Ein-karem hospital, Obstetrics and gynecology department, Jerusalem
Jerusalem, Yerushalayim, Israel
.jpg "Roie Alter, MD (he/him/his) photo")
Roie Alter, MD (he/him/his)
Hadassah Medical Center and Hebrew University of Jerusalem, Jerusalem, Israel
Jerusalem, Yerushalayim, Israel
Snir Tamari, MD
Hadassah Medical Center and Hebrew University of Jerusalem, Jerusalem, Israel
Hadassah Medical Center and Hebrew University of Jerusalem, Jerusalem, Israel, Yerushalayim, Israel
Hadar Rosen, MD
Hadassah Ein-karem hospital, Obstetrics and gynecology department, Jerusalem
Jerusalem, Yerushalayim, Israel
Doron Kabiri, MD
Hadassah Ein-karem hospital, Obstetrics and gynecology department, Jerusalem
Jerusalem, Yerushalayim, Israel
Migraine affects 15–20% of women of reproductive age, with peak incidence during the childbearing years. While previous studies have suggested an association between migraine and adverse pregnancy outcomes, findings have been inconsistent due to methodological limitations, such as small sample sizes and inadequate confounder control. This study aimed to evaluate the relationship between migraine and a comprehensive range of obstetric complications.
Study Design:
We conducted a retrospective cohort study using the TriNetX Collaborative Network, which includes de-identified electronic medical records from 70 healthcare organizations between March 2005, and January 2024.
Pregnant women aged 18–40 with a migraine diagnosis and no pre-pregnancy hypertension diagnosis were matched 1:1 to pregnant women without migraine (n=210,742 per group) using propensity scores based on age, race, BMI, tobacco use, and prior Cesarean delivery. Outcomes were defined using ICD-10 codes, procedures, or laboratory values.
Results:
Women with migraine demonstrated significantly increased risks across multiple adverse pregnancy outcomes compared to matched controls. The strongest associations were observed for hypertensive disorders: eclampsia (OR 1.87, 95%CI 1.66–2.10; 0.4% vs 0.2%), preeclampsia (OR 1.49, 95%CI 1.45–1.53; 7.3% vs 5.0%), and pregnancy-induced hypertension (OR 1.50, 95%CI 1.47–1.54; 9.8% vs 6.7%). Migraine was also associated with increased risk of preterm labor (OR 1.53, 95%CI 1.50–1.57; 8.9% vs 6.0%), abortion (OR 1.31, 95%CI 1.29–1.34; 8.9% vs 6.9%), gestational diabetes mellitus (OR 1.23, 95%CI 1.20–1.26; 8.7% vs 7.2%), placental abruption (OR 1.28, 95%CI 1.21–1.35; 1.3% vs 1.0%), and intrauterine fetal death (OR 1.25, 95%CI 1.17–1.35; 0.8% vs 0.6%).
Conclusion:
This large, matched propensity score cohort study demonstrates that migraine independently increases the risk of multiple adverse pregnancy outcomes. These findings indicate that migraine history should be considered an important risk marker in pregnancy, warranting enhanced surveillance and potentially preventive interventions for affected women.