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Poster Session 1

Category: Clinical Obstetrics

Poster Session 1

(124) Effect of Aspirin Exposure on Placental Pathology in Fetal Growth Restriction

Wednesday, February 11, 2026

10:30 AM - 12:00 PM

Presenting Author(s)

AL

Amberly Lao, MD

Resident Physician
NYU Langone Hospital- Long Island
NYU Langone Hospital- Long Island, New York, United States

Submitting Author(s)

Julia Kim, MD

Fellow, Maternal Fetal Medicine
NYU Grossman Long Island School of Medicine
Mineola, New York, United States

Coauthor(s)

JG

Justin Gimoto, MD

NYU Grossman Long Island School of Medicine
Mineola, New York, United States
MG

Maria Gomez, MD

Resident Physician
NYU Grossman Long Island School of Medicine
Mineola, New York, United States
Annie Rozenblyum, BA

Medical Student
NYU Grossman Long Island School of Medicine
Mineola, New York, United States
SK

Soo Young Kim, MA

NYU Grossman Long Island School of Medicine
Mineola, New York, United States
PK

Poonam Khullar, MD

Department of Pathology, NYU Grossman School of Medicine
Mineola, New York, United States
PR

Patricia Rekawek, MD

Clinical Associate Professor, Department of Obstetrics and Gynecology
NYU Grossman Long Island School of Medicine
Mineola, New York, United States
Martin Chavez, MD (he/him/his)

Professor of Obstetrics, Gynecology & Reproductive Medicine
NYU Grossman Long Island School of Medicine
Mineola, New York, United States
LP

Lakha Prasannan, MD

NYU Long Island
Long Island City, New York, United States

Objective:
Evaluation of placental pathology in fetal growth restriction (FGR) has been limited. Patients with FGR are often exposed to low-dose aspirin (LDA) for preeclampsia (PEC) p</span>revention due to shared mechanisms of placental insufficiency. However, data on placental findings in this context are scarce. The objective of this study was to evaluate the placental pathology in pregnancies complicated by FGR with and without LDA exposure.

Study Design:
This was a retrospective cohort study of singleton pregnancies complicated by FGR with confirmed small for gestational age (SGA) neonates at a single institution from 2020 to 2024. FGR was defined as an estimated fetal weight (EFW) and/or abdominal circumference (AC) < 10th percentile. Chromosomal abnormalities, major fetal anomalies, multiple gestations, delivery prior to 24 weeks, or discarded placentas were excluded. LDA was defined as 81mg or 162mg daily starting at 11 weeks. ANOVA and Pearson’s X² tests with p< 0.05 were used and multivariate regression was applied to adjust for confounders.

Results:

Among 111 pregnancies, 70 were not exposed and 41 were exposed to aspirin.

LDA exposed patients were more likely to have chronic hypertension (7.3% vs 0%, p=0.007) and autoimmune disease (7.3% vs 0%, p=0.02). Persistent muscularization was more frequent with aspirin (9.8% vs 1.4%, p=0.04), and segmental avascular villi were less frequent (0% vs 12.9%, p=0.02). Fetal vascular malperfusion was lower with aspirin (9.8% vs 20%), though not statistically significant. On multivariable regression, persistent muscularization lost significance; regression was not performed for segmental avascular villi due to low frequency.

Conclusion:
Aspirin exposure may reduce placental findings associated with fetal vascular malperfusion in FGR, particularly segmental avascular villi. Larger studies are needed to evaluate aspirin’s histopathologic impact in this high-risk cohort, including those who were eligible but did not receive aspirin.