Poster Session 2
Category: Prematurity
Poster Session 2
Rémi Micheletti, MD
Medical Resident in Obstetrics and Gynecology
Bordeaux University Hospital
Bordeaux Universitary Hospital, Aquitaine, France
Hugo Madar, MD, PhD (he/him/his)
Doctor of Medicine in Obstetrics and Gynecology – Maternal Fetal Medicine
Bordeaux University Hospital
Bordeaux Universitary Hospital, Aquitaine, France
Frédéric Coatleven, MD
Attending Physician in Obstetrics and Fetal Medicine
Bordeaux University Hospital
BORDEAUX, Aquitaine, France
Amaury Brot, MD
Attending Physician in Obstetrics and Fetal Medicine
Bordeaux University Hospital
Bordeaux Universitary Hospital, Aquitaine, France
Aurélien Mattuizzi, MD
Attending Physician in Obstetrics and Fetal Medicine
Bordeaux University Hospital
Bordeaux Universitary Hospital, Aquitaine, France
Marie Vincienne, MD
Attending Physician in Obstetrics and Fetal Medicine
Bordeaux University Hospital
Bordeaux Universitary Hospital, Aquitaine, France
Alizée Froeliger, MD
Attending Physician in Obstetrics
Bordeaux University Hospital
Bordeaux Universitary Hospital, Aquitaine, France
Loïc Sentilhes, FRCOG, MD, PhD (he/him/his)
Professor in Obstetrics and Gynecology – Maternal Fetal Medicine
Bordeaux University Hospital
Bordeaux Universitary Hospital, Aquitaine, France
Hanane Bouchghoul, MD, PhD (she/her/hers)
Associate Professor in Obstetrics and Gynecology – Maternal Fetal Medicine
Bordeaux University Hospital
Bordeaux Universitary Hospital, Aquitaine, France
The objective of this study was to evaluate the association between interval between antenatal corticosteroid administration and delivery across clinical indications.
Study Design:
This retrospective study included women with singleton pregnancies who received antenatal corticosteroids for one of four clinical indications: preeclampsia, preterm prelabor rupture of membranes (PPROM), fetal growth restriction (FGR), or threatened preterm labor (TPL). The interval between corticosteroid administration and delivery (days) was assessed using Kaplan–Meier survival analysis for each indication, and differences between indications were compared using the log-rank test. A multivariable Cox proportional hazards regression model was used to adjust for gestational age at corticosteroid administration (categorized), prior preterm birth, maternal age, BMI category, and previous cesarean.
Results:
A total of 312 patients were included: 71 (22.8%) with preeclampsia, 125 (40.1%) with PPROM, 44 with FGR (14.1%), and 72 with TPL (23.1%). The median interval between corticosteroid administration and delivery significantly differed across the four groups (log-rank p < 0.001), with the shortest interval observed in FGR and preeclampsia, and the longest in TPL. In the multivariable adjusted Cox model, the interval between corticosteroid administration and delivery remained significantly associated with the clinical indication. Compared to preeclampsia (reference group), the hazard of delivery was significantly lower in cases of TPL (HR = 0.47; 95% CI [0.30–0.74], p < 0.001), showed a trend toward being lower in PPROM (HR = 0.68; 95% CI [0.46–1.01], p = 0.054), and was not significantly different in FGR (HR = 0.93; 95% CI [0.59–1.47], p = 0.769).
Conclusion:
The interval between corticosteroid administration and delivery varies significantly by clinical indication. These findings suggest that timing of corticosteroid administration could consider the expected latency to delivery associated with each indication to optimize neonatal benefit.