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CME Credit Offered
CME Credit Offered
Abstract Award
Abstract Award
Recording available 2/16-5/2
Recording available 2/16-5/2
AIUM Credit
AIUM Credit
Foundation Awardee
Foundation Awardee
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Abstract Award
Abstract Award
Foundation Awardee
Foundation Awardee

Poster Session 2

Category: Perinatal Mental Health

Poster Session 2

(691) Placenta accreta spectrum and postpartum mental health: A global study

Wednesday, February 11, 2026
3:30 PM - 5:00 PM  
Objective:
Placenta accreta spectrum (PAS) is associated with an increased risk of perinatal mental health disorders (MHD). However, the lasting MHD for patients with PAS, specifically compared with other high-risk obstetric populations, remains unknown. The objective of the study was to determine the MHD toll on patients with PAS one year after delivery compared to patients at high risk of postpartum hemorrhage without PAS.

Study Design:
The study analyzed 2016-2024 data from the TriNetX Global Collaborative cohort which includes electronic health record data from 148 health care organizations. We included patients with prior cesarean delivery and placenta previa in the index pregnancy and dichotomized them to PAS and no PAS based on ICD-10 codes. Both groups were propensity score matched (PSM) on demographics, socioeconomic indicators and prior medical history including prior MHD. We assessed postpartum MHD diagnosis including anxiety, obsessive compulsive disorder, depression/other major depressive disorders, or stress disorders (including post-traumatic stress disorder) up to one year post-delivery. We used Cox regression to compare MHD between groups, reporting hazard ratios (HRs), and 95% confidence intervals (CIs).

Results:
After PSM, 2706 PAS patients matched 1:1 to those without PAS. The groups demonstrated a mean age of 32.8 ± 5.4 (PAS) and 32.7± 5.6 no PAS), the majority being white (PAS vs no PAS: 55% vs 54%) and non-Hispanic (57% vs 54%, respectively). Those with PAS were more likely to have a postpartum MHD diagnosis (HR 1.21, 95% CI 1.08–1.35) compared to those without PAS. PAS patients without a pre-existing MHD diagnosis were more likely to have a postpartum MHD diagnosis (HR 1.61, 95% CI 1.34–1.94) in the year after delivery when compared to those without PAS.

Conclusion:
Among a cohort of high-risk pregnancies, individuals with PAS were more likely to have a postpartum MHD diagnosis in the year after delivery when compared to those without PAS. Future research on potential intervention strategies is needed.