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CME Credit Offered
CME Credit Offered
Abstract Award
Abstract Award
Recording available 2/16-5/2
Recording available 2/16-5/2
AIUM Credit
AIUM Credit
Foundation Awardee
Foundation Awardee
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Abstract Award
Abstract Award
Foundation Awardee
Foundation Awardee

Poster Session 2

Category: Hypertension

Poster Session 2

(657) Peripartum cardiac stress markers among pregnancies with and without hypertensive disorder of pregnancy

Wednesday, February 11, 2026
3:30 PM - 5:00 PM  
Objective:
To evaluate maternal serum cardiac stress markers, NTproBNP and high-sensitivity troponin T (hsTropT) at time of delivery in patients with hypertensive disorders of pregnancy (HDP).

Study Design:
Prospective cohort study of patients ≥18 years with singleton pregnancy. Maternal blood was collected at time of delivery admission. Clinical variables including demographics, medical/obstetric history, pregnancy outcomes, and cardiovascular parameters including blood pressure and baseline labs were collected. NTproBNP and hsTropT were quantified using the Roche analyzer with electrochemiluminescence immunoassay. Levels were compared between those who developed HDP and those who did not. Measures of association with HDP were assessed using multivariable logistic regression and reported as OR and adjusted OR, adjusting for potential confounders.

Results:
Baseline characteristics were similar between groups. Time of delivery NTproBNP was increased in those with HDP vs no HDP (51.5 [18.0-107.0] vs 38.0 [18.0-60.0], p=0.01). HsTropT was also elevated in the HDP group vs no HDP group (3.0 [3.0-7.11] vs 3.0 [3.0-3.0], p < 0.001). Both hsTropT and NTproBNP were significantly associated with risk of HDP (OR [95% CI] 4.62 [2.25-9.88] and 2.42 [1.20-5.01], respectively).

Conclusion:
Elevated maternal serum NTproBNP and hsTropT at time of delivery were significantly associated with HDP, suggesting peripartum cardiac stress and subclinical myocardial injury may be more pronounced in individuals with HDP, even in the absence of overt cardiovascular disease. Measurement of NTproBNP and hsTropT in the peripartum period may offer insight into maternal cardiovascular strain and could represent potential biomarkers for identifying those at increased risk for HDP. Further research is warranted to assess their utility in risk stratification and their relationship to long-term cardiovascular outcomes.