Poster Session 3
Category: Obstetric Quality and Safety
Poster Session 3
Noam Shema, MD (he/him/his)
OB/GYN Resident
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University
Beer sheva, HaDarom, Israel
Tamar Wainstock, PhD (she/her/hers)
Department of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, Ben-Gurion University of the Negev
Beer Sheva, HaDarom, Israel
.jpeg.jpg "Eyal Sheiner, MD, PhD photo")
Eyal Sheiner, MD, PhD
Deichmann Lerner Full Professor of Obstetrics & Gynecology; Chairman of the Division of OBY&GYN
Soroka University Medical Center, Faculty of Health Sciences, Ben‑Gurion University of the Negev
beer sheva, HaDarom, Israel
Maternal asthma is a prevalent inflammatory condition during pregnancy. Emerging evidence suggests that maternal immune activation may influence fetal gastrointestinal development and function. We aimed to investigate whether maternal asthma is associated with increased long-term gastrointestinal morbidity in[אשפ1] the offspring.
[אשפ1]תברר עם שיר או מישהי אם לא אומרים of the offspring
A population-based cohort analysis was conducted, comparing the incidence of gastrointestinal-related pediatric morbidity (obtained from both hospital and community-based diagnoses) among offspring of mothers with and without asthma. The cohort included all singleton live births between 1991 and 2021 at a tertiary medical center. Infants with congenital malformations, multiple gestations, or perinatal mortality were excluded. A Kaplan-Meier survival curve compared cumulative incidence of gastrointestinal morbidity. A Cox proportional hazards model was used to control for relevant confounders.
The final cohort included 232,476 births, of which 2,875 (1.2%) were to mothers with asthma. Offspring of asthmatic mothers had significantly higher rates of gastrointestinal-related morbidity compared to those without maternal asthma (32.6% vs. 26.4%, OR = 1.3, 95% CI 1.24–1.45; p < 0.001; Table). Likewise, Kaplan–Meier analysis demonstrated a significantly increased cumulative incidence of gastrointestinal morbidity in the exposed group (log-rank p < 0.001; Figure). In a Cox regression model, maternal asthma remained an independent risk factor for gastrointestinal morbidity in the offspring (adjusted HR = 1.3, 95% CI 1.20–1.30; p < 0.001), after adjusting for confounders such as maternal age, gestational age at birth, gestational diabetes, hypertensive disorders, and cesarean delivery.
Maternal asthma is independently associated with an increased long-term gastrointestinal morbidity of the offspring. Maternal inflammatory and immune conditions during pregnancy may have long-lasting effects on fetal organ development.