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Poster Session 3

Category: Hypertension

Poster Session 3

(953) Risk factors associated with the development of severe preeclampsia with or without fetal growth restriction

Thursday, February 12, 2026

10:30 AM - 12:00 PM

Submitting Author and Presenting Author(s)

Sascha Wodoslawsky, MD

Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai
New York, New York, United States

Coauthor(s)

Mariam K. Ayyash, MD, MSCR

Clinical Fellow
Columbia University Irving Medical Center
New York, New York, United States
Rodney A. McLaren, Jr, MD

Maternal Fetal Medicine Attending
Maimonides Medical Center
Brooklyn, New York, United States
TG

Taryn Gallagher, BA

Sidney Kimmel Medical College at Thomas Jefferson University
Philadelphia, Pennsylvania, United States
MS

Madeline V. Smith, MPH

Sidney Kimmel Medical College at Thomas Jefferson University
Philadelphia, Pennsylvania, United States
SM

Sam Mauser, MD

Westchester Medical Center
Philadelphia, Pennsylvania, United States
LR

Leanna M. Reichert, BS

Sidney Kimmel Medical College at Thomas Jefferson University
Philadelphia, Pennsylvania, United States
Huda B. Al-Kouatly, MD

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA
Philadelphia, Pennsylvania, United States

Objective:
To identify maternal risk factors associated with the development of severe preeclampsia (PE) complicated by fetal growth restriction (FGR) compared with severe PE alone.

Study Design:
We conducted a retrospective cohort study of singleton pregnancies diagnosed with severe PE between March 2017 and June 2023 at a single health care system. Pregnancies were included if they had a first-trimester dating ultrasound, a completed anatomy between 18w0d and 24w0d, and were not affected by major structural or chromosomal abnormalities. Cases were stratified by the presence or absence of FGR, defined as an estimated fetal weight or abdominal circumference < 10th percentile for gestational age. Maternal demographic and clinical characteristics evaluated included body mass index (BMI) ≥30 kg/m², race, maternal age ≥35 years, history of chronic hypertension (cHTN), diabetes (pregestational or gestational), autoimmune disease, and renal disease. Comparisons between groups were performed using chi-square.

Results:
Out of 9386 maternal and neonatal charts and ultrasounds reviewed, 340 pregnancies had severe PE. Of those pregnancies, 61 (17.9%) were complicated by FGR. There were no significant differences in BMI ≥30 kg/m² (63.9% vs 76.0%, p=0.052), Black race (60.6% vs 58.4%, p=0.75), maternal age ≥35 years (24.6% vs 30.1%, p=0.39), cHTN (36.1% vs 34.8%, p=0.85), and pregestational diabetes (6.6% vs 7.2%, p=0.87) or gestational diabetes (8.2% vs 15.1%, p=0.16) between those with severe PE+FGR and severe PE alone. Autoimmune disease and renal disease were rare and did not differ by group (Table 1).

Conclusion:
No maternal demographic or clinical risk factors assessed in this study were significantly associated with the development of FGR among pregnancies complicated by severe preeclampsia. Further research is needed to better understand the pathophysiologic and maternal characteristics associated with the development of FGR in pregnancies complicated by severe preeclampsia.