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Poster Session 4

Category: Medical/Surgical/Diseases/Complications

Poster Session 4

(1012) Pregnant patients with Neurofibromatosis 2 and associated perinatal and maternal outcomes: a systematic review

Thursday, February 12, 2026

3:30 PM - 5:00 PM

Submitting Author and Presenting Author(s)

Alexandra Mahdasian-Miller, MD (she/her/hers)

Fellow Physician
Vanderbilt University Medical Center
Nashville, Tennessee, United States

Coauthor(s)

Amelie Pham, MD

Maternal Fetal Medicine Specialist
Vanderbilt University Medical Center
Nashville, Tennessee, United States
MN

Megan Nocita, MD

Vanderbilt University Medical Center
Nashville, Tennessee, United States
MS

Motolani Shonibare, PhD

Vanderbilt University Medical Center
Nashville, Tennessee, United States

Objective:
To perform a systematic review of the existing literature on maternal neurofibromatosis 2 (NF2) in pregnancy and add a new case report to consolidate the best available evidence regarding associated adverse maternal and neonatal outcomes.

Study Design:
A systematic review registered with PROSPERO in 7/2024 and followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines. A comprehensive search of PubMed, Embase, CINAHL, Scopus, Cochrane, and ClinicalTrials.gov was conducted through November 19, 2024. Search terms included various combinations of “neurofibromatosis 2” and “pregnancy”. Studies were excluded if no case of maternal NF2 in pregnancy was reported. Screening involved two independent reviewers, with conflicts resolved by a third reviewer. Study quality was assessed with the proposed tool set forth by Murad et. Al for case series and reports.

Results:
Of the 2946 studies initially screened, 9 studies met inclusion criteria. These included 6 case studies, 2 prospective cohort studies and a retrospective cohort study with a total of 123 cases of NF2 in pregnancy, including a new case report from our institution (Table 1). Study bias-risk assessment yielded a majority of low-quality data. The most common maternal adverse outcome reported was advancing neurologic disease (8/75, 11%) and hypertensive disorder of pregnancy (< 12/53, < 23%). The need for neurological surgical intervention during pregnancy was rare (1/75, 1%). There was 1 case of reported iatrogenic preterm birth for fetal indications among < 11/80 (< 14%) cases of preterm birth (see Table 2). All patients with reported birth outcome (N=80) had a live birth.

Conclusion:
Maternal NF2 in pregnancy is rare with few cases described in the literature. Our study summarizes for the largest sample of reported NF2 cases in pregnancy, adding a new case to the existing literature, and underscores the complexity of this maternal condition. Overall birth outcomes were favorable. Further research is needed to better inform clinical management of NF2 in pregnancy and enhance patient counseling.