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Recording available 2/16-5/2
Recording available 2/16-5/2
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Abstract Award
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Poster Session 4

Category: Clinical Obstetrics

Poster Session 4

(1034) Effect of Antenatal Corticosteroids on Placental Histology in Growth-Restricted Fetuses

Thursday, February 12, 2026
3:30 PM - 5:00 PM  

    Presenting Author(s)

  • Annie Rozenblyum, BA

    Medical Student
    NYU Grossman Long Island School of Medicine
    Mineola, New York, United States

    • Submitting Author(s)

  • Julia Kim, MD

    Fellow, Maternal Fetal Medicine
    NYU Grossman Long Island School of Medicine
    Mineola, New York, United States

    • Coauthor(s)

  • AL

    Amberly Lao, MD

    Resident Physician
    NYU Langone Hospital- Long Island
    NYU Langone Hospital- Long Island, New York, United States

  • JG

    Justin Gimoto, MD

    NYU Grossman Long Island School of Medicine
    Mineola, New York, United States

  • MG

    Maria Gomez, MD

    Resident Physician
    NYU Grossman Long Island School of Medicine
    Mineola, New York, United States

  • SK

    Soo Young Kim, MA

    NYU Grossman Long Island School of Medicine
    Mineola, New York, United States

  • PK

    Poonam Khullar, MD

    Department of Pathology, NYU Grossman School of Medicine
    Mineola, New York, United States

  • PR

    Patricia Rekawek, MD

    Clinical Associate Professor, Department of Obstetrics and Gynecology
    NYU Grossman Long Island School of Medicine
    Mineola, New York, United States

  • Martin Chavez, MD (he/him/his)

    Professor of Obstetrics, Gynecology & Reproductive Medicine
    NYU Grossman Long Island School of Medicine
    Mineola, New York, United States

  • LP

    Lakha Prasannan, MD

    NYU Long Island
    Long Island City, New York, United States

Objective:
Antenatal corticosteroids (ACS) are frequently administered to patients with fetal growth restriction (FGR) due to risk of preterm delivery; however, data on the histopathologic impact of ACS exposure on the placenta in this context are limited. The objective of this study was therefore to evaluate placental pathology in pregnancies complicated by FGR and exposed to ACS.

Study Design:
This was a retrospective cohort study of singleton pregnancies complicated by FGR with confirmed small for gestational age (SGA) neonates at a single institution from 2020 to 2024. FGR was defined as an estimated fetal weight (EFW) and/or abdominal circumference (AC) < 10th percentile. Chromosomal abnormalities, major fetal anomalies, multiple gestations, delivery prior to 24 weeks, or discarded placentas were excluded. ACS exposure was defined as receiving either a complete or incomplete course of betamethasone. ANOVA and X2 tests with p< 0.05 were used.

Results:

Among 111 pregnancies complicated by FGR, 93 were exposed to ACS and 18 were not. Those with ACS exposure were more likely to have severe FGR at time of delivery (50% vs 11%, p=0.008), abnormal umbilical artery dopplers (43% vs 11%, p=0.01) and deliver earlier (35.1 vs 37.7 weeks p< 0.001).There were no significant differences in placental findings between the two groups. Increased rates of intraparenchymal hematoma (14% vs 0%), accelerated villous maturation (14% vs 0%), fetal vascular malperfusion (18.3% vs 5.6%) and segmental avascular villi (9.7% vs 0%) were noted, though not statistically significant. 


Conclusion:
No significant differences in placental pathology were identified between FGR pregnancies with and without ACS exposure, although trends toward increased placental abnormalities were noted in the ACS group. These findings may reflect greater disease severity rather than a direct effect of ACS. Future research should stratify by timing of ACS, particularly within the second trimester, to better assess the relationship between ACS exposure and placental pathology.