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CME Credit Offered
CME Credit Offered
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Abstract Award
Recording available 2/16-5/2
Recording available 2/16-5/2
AIUM Credit
AIUM Credit
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Foundation Awardee
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Abstract Award
Abstract Award
Foundation Awardee
Foundation Awardee

Poster Session 2

Category: Diabetes

Poster Session 2

(687) Impact of Hypoglycemia During Glucose Testing in Pregnancy on Maternal and Neonatal Outcomes

Wednesday, February 11, 2026
3:30 PM - 5:00 PM  
Objective:
Hypoglycemia in pregnancy, defined as a blood glucose level < 60 mg/dL, has been inconsistently linked to adverse obstetrical outcomes, and available data remains scant. our study aimed to assess the association between hypoglycemia during the glucose challenge test (GCT, 50 g) and the oral glucose tolerance test (OGTT, 100 g) in pregnancy, and the risk of adverse maternal and neonatal outcomes.

Study Design:
A multicenter retrospective cohort study was conducted, while including pregnant women who experienced hypoglycemia during either the GCT or OGTT. Women with hypoglycemia on each test were compared to those with normal glucose levels. Analyses included univariate comparisons followed by multivariable logistic regression.

Results:
Of the cohort, 2.2% (n = 2,921/145,978) had hypoglycemia during the GCT, and 16.4% (n = 3,441/30,264) had at least one hypoglycemic value during the OGTT. In multivariable analysis, hypoglycemia during GCT was independently associated with lower rates of delivering a large-for-gestational-age (LGA) neonate (adjusted odds ratio [aOR] 0.53, 95% CI 0.39–0.73), but with higher rates of a small-for-gestational-age (SGA) neonate (aOR 1.56, 95% CI 1.24–1.97). No independent association was found between hypoglycemia on either test and overall adverse neonatal outcomes after adjustment.

Conclusion:
In this large multicenter cohort, hypoglycemia during the GCT was associated with an increased risk of SGA but not with a higher risk of composite adverse neonatal outcomes. These findings may provide reassurance to clinicians and patients and help avoid unnecessary interventions.